HCID 58529308, compound → HCID 58529650, compound

HRID 1972960Notes

Reaction equation

HRID 1972960 reaction equation
[NH2:1][C:2]1[C:7]2=[C:8]([Br:24])[CH:9]=[C:10]([CH:11]3CCN(C(OC(C)(C)C)=O)[CH2:13][CH2:12]3)[N:6]2[N:5]=[CH:4][N:3]=1.NC1C2=CC=C(C([OH:38])CC)N2N=CN=1>>[NH2:1][C:2]1[C:7]2=[C:8]([Br:24])[CH:9]=[C:10]([CH:11]([OH:38])[CH2:12][CH3:13])[N:6]2[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 58529308HCID 58529308, compoundHCID 59231971HCID 59231971, compound

Product 1

HCID 58529650HCID 58529650, compound

Procedure

This compound was prepared in a manner similar to the bromination procedure described for the preparation of tert-butyl 4-(4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate, using 1-(4-amino-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-propan-1-ol as the starting material. 1H NMR (300 MHz, DMSO-d6) δ 7.78 (s, 1H), 7.59 (broad s, 6.80 (d, 1H), 6.52 (d, 1H), 5.11 (d, 1H), 4.98 to 4.93 (m, 1H), 1,83 to 1.66 (m, 2H), 0.84 (t, 3H); ES-MS m/z 271.3/273.1 [M+H]+, RT (min) 1.86.

Workup

  1. customThis compound was prepared in a manner similar to the bromination procedure
  2. customm/z 271.3/273.1 [M+H]+, RT (min) 1.86

Sources & evidence

ORD record
ord-e606f7a42b764f309008fa64479a768a
Source dataset
uspto-grants-2013_04
Patent number
US08431695B2

Reaction notes

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