Ammonium formate → HCID 69304361, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 4-(4-amino-6-cyanopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,6-dihydropyridine-1(2H)-carboxylate (160 mg, 0.47 mmol) in MeOH (32 mL) and EtOAc (16 mL), was added Pd(OH)2 (164 mg, 0.118 mmol) followed by ammonium formate (592 mg, 9.40 mmol). The mixture was heated at 65° C. for 1.5 h then cooled to rt. The mixture was filtered through Celite® and the cake was washed with EtOAc (10 mL) and MeOH (10 mL). The filtrate was concentrated to dryness. ISCO® purification (50% EtOAc/Hexane) afforded pure product (56.6 mg, 35%). 1H NMR (400 MHz, DMSO-d6 δ 8.08 (s, 2H), 7.98 (s, 1H), 7.23 (s, 1H), 4.12-4.04 (m, 4H), 3.59-3.50 (m, 1H), 1.98-1.78 (m, 4H), 1.41 (s, 9H); LC-MS m/z[M+H]+ 343.1, RT 3.05 min.

Provenance & Evidence