N-bromobutanimide → HCID 71134226, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of tert-butyl 4-(4-amino-6-cyanopyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate (54 mg, 0.158 mmol) in DMF (2 mL), NBS (28.07 mg, 0.158 mmol) was added. The mixture was stirred at 0° C. for 2 h. The mixture was concentrated to dryness. Trituration with acetone afforded product (60 mg, 90%). 1H NMR (400 MHz, DMF-da) 7.52 (s, 1H), 4.42-4.38 (m, 4H), 4.88-4.78 (m, 1H), 2.20-2.08 (m, 4H), 1.62 (s, 9H); LC-MS m/z [M+H]+ 420.9% 422.9, LC-MS RT 3.24 min.

Provenance & Evidence