HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-(methylthio)benzo[d]thiazole → 2-Benzyl-5-bromo-1,3-benzothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-(methylthio)benzo[d]thiazole | HCID 2801271 | — |
| Reactant | 5-(2-Benzyl-1,3-benzothiazol-6-yl)-7-piperidin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine | HCID 58529360 | — |
| Reactant | HCID 178419772 | HCID 178419772 | — |
| Product | 2-Benzyl-5-bromo-1,3-benzothiazole | HCID 58529392 | 48% |
Reaction Steps
In a manner similar to the procedure described for Step 2 of the preparation of 5-(2-benzyl-1,3-benzothiazol-6-yl)-7-piperidin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine and using 5-bromo-2-(methylthio)-1,3-benzothiazole and benzylzinc bromide as starting material, 1.30 g (48%) of the desired product was isolated. 1H NMR (400 MHz, DMSO-d6) δ 8.18 (s, 1H), 7.99 (d, 1H), 7.56 (d, 1H), 7.40-7.18 (m, 5H), 4.44 (s, 2H); LC-MS m/z [M+H]+304.3 & 306.3, RT 5.16 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431695B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-400d9931751f4ecfb9c35f875b07f298 |
| Source note | uspto-grants-2013_04 |