3-Benzyloxy-phenylboronic acid → HCID 58529891, compound

HRID 1972995Notes

Reaction equation

HRID 1972995 reaction equation
[NH2:1][C:2]1[C:7]2=[C:8](Br)[CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]3)[N:6]2[N:5]=[CH:4][N:3]=1.[CH2:25]([O:32][C:33]1[CH:34]=[C:35](B(O)O)[CH:36]=[CH:37][CH:38]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[NH2:1][C:2]1[C:7]2=[C:8]([C:35]3[CH:36]=[CH:37][CH:38]=[C:33]([O:32][CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH:34]=3)[CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]3)[N:6]2[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 27343133-Benzyloxy-phenylboronic acidHCID 59231971HCID 59231971, compound

Product 1

HCID 58529891HCID 58529891, compoundYield 88%

Procedure

In a manner similar to the procedure described for step 7 of Example 330 and using tert-butyl 4-(4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate and (3-benzyloxyphenyl)boronic acid as starting material, 300 mg (88%) of the desired product was isolated. LC-MS m/z [M+H]+500.2, RT 3.47 min.

Sources & evidence

ORD record
ord-7b35d4ebb37a424fb1cf9d4d0b993eef
Source dataset
uspto-grants-2013_04
Patent number
US08431695B2

Reaction notes

Loading…