N,N-Dimethylglycine → HCID 58529790, compound

Participants

Reaction Steps

In a manner similar to the procedure described for the preparation of Example 342 and using 5-(3-benzyloxyphenyl)-7-piperidin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine and N,N-dimethylglycine as starting material, 20 mg (24%) of the desired product was isolated. 1H NMR (400 MHz, DMSO-d6) δ 7.90 (s, 1H), 7.45-7.30 (m, 6H), 7.10 (s, 1H), 7.05-6.97 (m, 2H), 6.56 (s, 1H), 5.13 (s, 2H), 4.48-4.42 (m, 1H), 4.18-4.12 (m, 1H), 3.41-3.32 (m, 3H), 3.20-3.10 (m, 2H), 3.05-2.97 (m, 1H), 2.76-2.68 (m, 1H), 2.16 (s, 6H), 2.06-1.98 (m, 2H); LC-MS m/z [M+H]+ 485.3, RT 2.32 min.

Provenance & Evidence