2-chloro-N,N-dimethylacetamide → HCID 58529411, compound

Participants

Reaction Steps

In a manner similar to the procedure described for the preparation of Example 355 and using 5-(3-benzyloxyphenyl)-7-piperidin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine and 2-chloro-N,N-dimethylacetamide as starting material, 20 mg (23.6%) of the desired product was isolated. 1H NMR (400 MHz, DMSO-d5) δ 7.90 (s, 1H), 7.44-7.32 (m, 6H), 7.10 (s, 1H), 7.02-6.98 (m, 2H), 6.59 (s, 1H), 5.16 (s, 2H), 3.16 (s, 2H), 3.15-3.04 (m, 1H), 3.03 (s, 3H), 2.97-2.90 (m, 2H), 2.80 (s, 3H), 2.22-2.14 (m, 2H), 1.98-1.92 (m, 2H), 1.74-1.64 (m, 2H); LC-MS m/z [M+H]+485.2, RT 2.29 min.

Provenance & Evidence