Acetyl chloride → HCID 71134438, compound

Participants

Reaction Steps

In a manner similar to the procedure described for the preparation of Example 331 and using 3-(4-amino-7-piperidin-4-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-benzylbenzamide and acetyl chloride as starting material, 20 mg (26.0%) of the desired product was isolated. 1H NMR (400 MHz, CD3OD) δ 7.98 (s, 1H), 7.88-7.82 (m 2H), 7.62 (d, 1H), 7.55 (t, 1H), 7.36-7.28 (m, 4H), 7.25-7.20 (m, 1H), 6.58 (s, 1H), 4.67-4.59 (m, 3H), 4.06-3.98 (m, 1H), 3.52-3.43 (m, 1H), 3.33-3.24 (m, 1H), 2.78 (td, 1H), 2.20-2.08 (m, 5H), 1.73-1.63 (m, 2H); LC-MS m/z [M+H]+469.3, RT 2.34 min.

Provenance & Evidence