1,3-Dibromo-5,5-dimethylhydantoin → HCID 58529796, compound

Participants

Reaction Steps

A stirred solution of 5-(2-benzyl-2H-indazol-6-yl)-2-methylpyrrolo[2,1-f][1,2,4]triazin-4-amine (130 mg, 0.367 mmol) in dichloromethane (10 mL) was cooled (−30° C.) under nitrogen atmosphere, and a solution of 1,3-dibromo-5,5-dimethyl-imidazolidine-2,4-dione (52.4 mg, 0.183 mmol) in dichloromethane (10 mL) was added dropwise. After 35 min, the mixture was concentrated in vacuo and purified via MPLC (hexanes/ethyl acetate gradient) to afford 148 mg (93%) of sand-colored solid. 1H-NMR (CD2Cl2): δ 8.04 (d, 1 H), 7.77 (dd, 1 H), 7.73 (dd, 1 H), 7.40-7.31 (m, 5 H), 7.18 (dd, 1 H), 6.75 (s, 1 H), 5.61 (s, 2 H), 5.52 (br s, 2 H), 2.41 (s, 3 H). MS: LC/MS (+esi), m/z=433 [M+H]. RT=2.88 min.

Provenance & Evidence