Chloride → HCID 58529298, compound

Participants

Reaction Steps

In a manner similar to the procedure described for Example 369 and using 7-piperidin-4-yl-5-[2-(pyridin-3-ylmethyl)-2H-indazol-6-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amine and substituting dimethylcarbamyll chloride for 2-chloro-N,N-dimethylacetamide as starting material, 50 mg (65%) of the desired product was isolated. 1H NMR (400 MHz, CD3OD) δ 8.57 (s, 1 H) 8.49 (d, 1 H) 8.43 (s, 1 H) 7.75-7.80 (m, 3 H) 7.63 (s, 1 H) 7.42 (dd, 1 H) 7.21 (d, 1 H) 6.56 (s, 1 H) 5.71 (s, 2 H) 3.76 (d, 2 H) 3.34 (m, 1 H) 2.94 (dd, 2 H) 2.84 (s, 6 H) 2.06 (dd, 2 H) 1.73 (dt, 2 H). LC-MS [M+H]+=496.4, RT=1.08 min.

Provenance & Evidence