2-chloro-N,N-dimethylacetamide → HCID 58529465, compound

Participants

Reaction Steps

In a manner similar to the procedure described for Example 369 and using 7 7-piperidin-4-yl-5-[2-(pyridin-2-ylmethyl)-2H-indazol-6-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amine and substituting acetyl chloride for 2-chloro-N,N-dimethylacetamide as starting materials, 43 mg (83%) of the desired product was isolated. 1H NMR (400 MHz, CD2Cl2) δ 8.58 (d, 1 H) 8.41 (s, 1 H) 7.65-7.81 (m, 3 H) 7.39 (s, 1 H) 7.19-7.26 (m, 3 H) 6.57 (s, 1 H) 5.78 (s, 2 H) 4.68 (d, 1 H) 4.02 (d, 1 H) 3.21-3.41 (m, 2 H) 2.76 (dd, 1 H) 2.01-2.19 (m, 5 H) 1.87 (dt, 2 H) LC-MS [M+H]+=467.4, RT=2.07 min.

Provenance & Evidence