2-chloro-N,N-dimethylacetamide → HCID 58529707, compound

Participants

Reaction Steps

In a manner similar to the procedure described for Example 369 and using 5-[2-(cyclohexylmethyl)-2H-indazol-6-yl]-7-piperidin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine and substituting acetyl chloride for 2-chloro-N,N-dimethylacetamide as starting materials, 13 mg (16%) of the desired product was isolated. 1H NMR (400 MHz, CD3OD) δ 8.25 (s, 1 H) 7.82 (s, 1 H) 7.80 (d, 1 H) 7.64 (d, 1 H) 7.21 (dd, 1 H) 6.60 (s, 1 H) 4.65 (dd, 1 H) 4.26-4.31 (m, 2 H) 4.04 (dd, 1 H) 3.50 (dt, 1 H) 3.27 (dd, 1 H) 2.80 (dd, 1 H) 2.12-222 (m, 6H) 1.67-1.77 (m, 7 H) 1.06-1.29 (m, 5 H). LC-MS [M+H]+=472.3, RT=2.66 min.

Provenance & Evidence