2-chloro-N,N-dimethylacetamide → HCID 58529270, compound

HRID 1973021Notes

Reaction equation

HRID 1973021 reaction equation
[CH:1]1([CH2:5][N:6]2[CH:14]=[C:13]3[C:8]([CH:9]=[C:10]([C:15]4[CH:16]=[C:17]([CH:25]5[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]5)[N:18]5[C:23]=4[C:22]([NH2:24])=[N:21][CH:20]=[N:19]5)[CH:11]=[CH:12]3)=[N:7]2)[CH2:4][CH2:3][CH2:2]1.Cl[CH2:32][C:33](N(C)C)=[O:34]>>[C:33]([N:28]1[CH2:29][CH2:30][CH:25]([C:17]2[N:18]3[C:23]([C:22]([NH2:24])=[N:21][CH:20]=[N:19]3)=[C:15]([C:10]3[CH:11]=[CH:12][C:13]4[C:8]([CH:9]=3)=[N:7][N:6]([CH2:5][CH:1]3[CH2:2][CH2:3][CH2:4]3)[CH:14]=4)[CH:16]=2)[CH2:26][CH2:27]1)(=[O:34])[CH3:32]

Participants

3

Reactant 2

HCID 758862-chloro-N,N-dimethylacetamideHCID 58529777HCID 58529777, compound

Product 1

HCID 58529270HCID 58529270, compoundYield 62%

Procedure

In a manner similar to the procedure described for Example 369 and using 5-[2-(cyclobutylmethyl)-2H-indazol-6-yl]-7-piperidin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine and substituting acetyl chloride for 2-chloro-N,N-dimethylacetamide as starting materials, 48 mg, (62%) of the desired product was isolated. LC-MS [M+H]+=444.3, RT=2.37 min.

Sources & evidence

ORD record
ord-da58f3335db84934b0279f812ac41b65
Source dataset
uspto-grants-2013_04
Patent number
US08431695B2

Reaction notes

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