Piperazine → Trifluoroacetylpiperazine

Participants

Reaction Steps

Ethyl trifluoroacetate (34.54 mL, 287.33 mmol) was added to a suspension of piperazine (25.0 g, 287.33 mmol) in THF (250 mL) at room temperature under nitrogen and stirred for 30 min and concentrated to remove solvent. The oily residue was taken up in ether and filtered and the filter cake was washed with ether. The filtrate was concentrated to give a clear oil (24.37 g, 47%). LC-MS [M+H]+=183.1, RT=1.07 min.

Provenance & Evidence