HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → Methyl 5-bromo-3-phenylbenzo[b]thiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 3-Phenylbenzo[b]thiophene-2-carboxylic acid methyl ester | HCID 22763504 | — |
| Reactant | Sodium Bisulfite | HCID 23665763 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Methyl 5-bromo-3-phenylbenzo[b]thiophene-2-carboxylate | HCID 22763497 | — |
Reaction Steps
Add 29.3 g. bromine (10 ml; 0.37 mole) to 8.0 g. (0.03 mole) of methyl 3-phenylbenzo [b ]thiophene-2-carboxylate in 100 ml. of acetic acid and stir the mixture overnight at room temperature. Add a saturated solution of sodium bisulfite. Decant the supernatant and wash the oil with water. Triturate with methanol. Recrystallize from methanol to yield the title compound; m.p. 125°-126°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03996159 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-4610b380c7a64ce7bf6a4ac3fd9903ff |
| Source note | uspto-grants-1976_12 |