HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Bromo-3-phenylbenzo[b]thiophene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 5-bromo-3-phenylbenzo[b]thiophene-2-carboxylate | HCID 22763497 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Bromo-3-phenylbenzo[b]thiophene-2-carboxylic acid | HCID 22763468 | — |
Reaction Steps
Heat three grams of methyl 5-bromo-3-phenylbenzo [b ]thiophene-2-carboxylate in a mixture of 50 ml. of methanol and 30 ml. of 10% sodium hydroxide, under reflux for 1 hour. Add concentrated hydrochloric acid to yield the title compound as a precipitate. Recrystallize from benzene; m.p. 265°-266°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03996159 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-03ede7c77ba84e67a8e8082f56b7ae01 |
| Source note | uspto-grants-1976_12 |