HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (5-Chloro-3-phenyl-1-benzofuran-2-yl)methanamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Borane | HCID 6331 | — |
| Reactant | 5-Chloro-3-phenyl-1-benzofuran-2-carbonitrile | HCID 22763467 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (5-Chloro-3-phenyl-1-benzofuran-2-yl)methanamine hydrochloride | HCID 22763506 | — |
Reaction Steps
Treat 2.0 g. 2-cyano-5-chloro-3-phenylbenzofuran (0.008 mole) in 30 ml of tetrahydrofuran with 18 ml of borane in tetrahydrofuran (1 m solution). Reflux for 2 hours. Cool, add 10 ml of 10% hydrochloric acid and reflux for 1/2 hour. Evaporate the solution to dryness. Dissolve the residue in 50 ml of ethanol. Add 30 ml of ethanol saturated with hydrogen chloride. Dry the precipitate obtained to yield the title compound; m.p. 254°-256°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03996159 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-02cf2179bba7498a9e959b46be91ec3b |
| Source note | uspto-grants-1976_12 |