Methanol → 2-Iodo-4-methoxybenzoic acid

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Reaction Steps

205 G. of 2-iodo-4methoxy-benzoic acid methyl ester, 400 ml. of methanol, 390 ml. of water and 95 g. of potassium hydroxide are stirred at 48° C. for 30 minutes. The solution is then concentrated under reduced pressure and acidified with aqueous hydrochloric acid. The yellow crystalline 2-iodo-4-methoxy-benzoic acid obtained is removed by filtration, washed neutral with water and dried, melting point 185° C.

Provenance & Evidence