HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 8-Fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]-thiepin-10-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 8-fluoro-2-methyl-dibenzo[b,f]thiepin-10(11H)-one | HCID 12275541 | — |
| Solvent | Water | HCID 962 | — |
| Product | 8-Fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]-thiepin-10-ol | HCID 12275542 | — |
Reaction Steps
103 G. of 8-fluoro-2-methyl-dibenzo[b,f]thiepin-10(11H)-one are suspended in 550 ml. of ethanol and treated with 24.3 g. of sodium borohydride. The mixture is heated under reflux for about 10 minutes. After the addition of water, the mixture is extracted with chloroform. The organic phase is washed with water, dried over sodium sulfate, evaporated, and there is obtained 8-fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]thiepin-10-ol as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03996229 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-fe1b10b4f2be4ef197af9830db075d9b |
| Source note | uspto-grants-1976_12 |