HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 10-Chloro-8-fluoro-10,11-dihydro-2-methyldibenzo[b,f]thiepin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Calcium Chloride | HCID 5284359 | — |
| Reactant | 8-Fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]-thiepin-10-ol | HCID 12275542 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 10-Chloro-8-fluoro-10,11-dihydro-2-methyldibenzo[b,f]thiepin | HCID 12275543 | — |
Reaction Steps
103 G. of 8-fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]thiepin-10-ol, 500 ml. of benzene and 38.4 g. of finely powdered calcium chloride are saturated with hydrogen chloride gas at 15° C. and stirred overnight. The precipitate is removed by filtration, washed with benzene, evaporated under reduced pressure, and there is obtained 10-chloro-8-fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]-thiepin which melts at 63°-64° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03996229 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-7a9004a867ad4db584eeed8cc853a1e5 |
| Source note | uspto-grants-1976_12 |