HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Piperazinecarboxylic acid, ethyl ester → HCID 20328334, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Piperazinecarboxylic acid, ethyl ester | HCID 8431 | — |
| Reactant | 10-Chloro-8-fluoro-10,11-dihydro-2-methyldibenzo[b,f]thiepin | HCID 12275543 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 20328334 | HCID 20328334 | — |
Reaction Steps
24 G. of 10-chloro-8-fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]thiepin in 80 ml. of chloroform are heated under reflux for 20 hours with 38.4 g. of 1-carbethoxy-piperazine. The mixture is poured on to ice-water and extracted with chloroform. The organic phase is dried over magnesium sulfate, evaporated under reduced pressure, and there is obtained crude, oily 1-carbethoxy-4-[8-fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]thiepin-10-yl]-piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03996229 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-41517b8776cb4ead84da06a67951f849 |
| Source note | uspto-grants-1976_12 |