Ethylene Glycol → HCID 20328332, compound

Participants

Reaction Steps

24.5 G. of 1-carbethoxy-4-[8-fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]thiepin-10-yl]-piperazine, 350 ml. of ethyleneglycol, 19 g. of potassium hydroxide and 15 ml. of water are heated at 160° C. for 1 hour. The mixture is poured into water and extracted with chloroform. The organic phase is washed with water, dried over magnesium sulfate, evaporated under reduced pressure, and there is obtained 1-[8-fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]thiepin-10-yl]-piperazine as a light-brown oil.

Provenance & Evidence