反应详情

温度

90 °C

A suspension of methanesulfonic acid (7R,8S)-8-methanesulfonyloxymethyl-1,4-dioxaspiro-[4.4]non-7-ylmethyl ester (0.250 g, 0.73 mmol) in n-butylamine (1 ml) is heated at 90° C. for 3 hours. The reaction is evaporated and partitioned between EtOAc and 2M aqueous NaOH. The organic phase is washed with brine, dried (MgSO4) and evaporated. The crude product is purified by flash chromatography, eluting with EtOAc to afford (3aR,6aS)-2-butylspiro[hexahydrocyclopenta[c]pyrrole-5(1H),2′-[1,3]dioxolane], M+226.

1. customThe reaction is evaporated
2. custompartitioned between EtOAc and 2M aqueous NaOH
3. washThe organic phase is washed with brine
4. dry with materialdried (MgSO4)
5. customevaporated
6. customThe crude product is purified by flash chromatography
7. washeluting with EtOAc