反应详情

34.5 g. of 6-chloro-4-[[3-(dimethylamino)propyl]amino]-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester (0.1 Mol.) are dissolved in 200 ml. of methanol. A mixture of 15 g. of triethylamine and 6 g. of ethylamine are added and the solution is refluxed for one hour with stirring. The solvent is distilled off in vacuo and the residue treated with about 100 ml. of water. The aqueous phase is extracted three times with 100 ml. portions of ether, the ether layers are combined, dried over calcium chloride and the solvent distilled off. The resulting yellow oil is recrystallized from ether/ligroin, yield 31 g. (88%), m.p. < 20°.

1. additionA mixture of 15 g
2. temperaturethe solution is refluxed for one hour
3. distillationThe solvent is distilled off in vacuo
4. additionthe residue treated with about 100 ml
5. extractionThe aqueous phase is extracted three times with 100 ml
6. dry with materialdried over calcium chloride
7. distillationthe solvent distilled off
8. customThe resulting yellow oil is recrystallized from ether/ligroin, yield 31 g