Ethylamine → 4-Butylamino-6-ethylamino-2methyl-5-nitropyridine-3-carboxylic acid ethyl ester

HRID 1973108Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:21])=[N:8][C:9](Cl)=[C:10]([N+:17]([O-:19])=[O:18])[C:11]=1[NH:12][CH2:13][CH2:14][CH2:15][CH3:16])=[O:5])[CH3:2].[CH2:22]([NH2:24])[CH3:23]>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:21])=[N:8][C:9]([NH:24][CH2:22][CH3:23])=[C:10]([N+:17]([O-:19])=[O:18])[C:11]=1[NH:12][CH2:13][CH2:14][CH2:15][CH3:16])=[O:5])[CH3:2]

Participants

Reactant 2

HCID 6341Ethylamine

HCID 123875984-Butylamino-6-chloro-2-methyl-5-nitronicotinic acid ethyl ester

Product 1

HCID 123876034-Butylamino-6-ethylamino-2methyl-5-nitropyridine-3-carboxylic acid ethyl esterYield 86%

Procedure

4-Butylamino-6-chloro-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester is treated with ethylamine according to the procedure in Example 1 c and 4-butylamino-6-ethylamino-2methyl-5-nitropyridine-3-carboxylic acid ethyl ester is obtained, yield 86%, m.p. 53°-55° (methanol).

Sources & evidence

ORD record: ord-a123ddc2f86e461b8ce5cc65836058be
Source dataset: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03996233

Reaction notes

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