1-(2-Hydroxyethyl)piperazine → HCID 21492769, compound

HRID 1973132Notes

Reaction equation

HRID 1973132 reaction equation
Br[C:2]1[N:6]2[C:7]3[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][C:8]=3[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)=[N:10][CH2:11][C:5]2=[N:4][N:3]=1.[OH:25][CH2:26][CH2:27][N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[N+:22]([C:19]1[CH:20]=[CH:21][C:7]2[N:6]3[C:2]([N:31]4[CH2:32][CH2:33][N:28]([CH2:27][CH2:26][OH:25])[CH2:29][CH2:30]4)=[N:3][N:4]=[C:5]3[CH2:11][N:10]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)[C:8]=2[CH:18]=1)([O-:24])=[O:23]

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 21492806HCID 21492806, compound

Product 1

HCID 21492769HCID 21492769, compound

Procedure

In the manner given in Example 1, 1-bromo-8-nitro-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated with excess 1-(β-hydroxyethyl)piperazine to give 8-nitro-1-[4-(β-hydroxyethyl)piperazino]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-110ea67ebf774a4d9790fd4fccbf2e52
Source dataset
uspto-grants-1976_12
Patent number
US03996230

Reaction notes

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