1-(2-Hydroxyethyl)piperazine → HCID 21492827, compound

HRID 1973138Notes

Reaction equation

HRID 1973138 reaction equation
Br[C:2]1[N:6]2[C:7]3[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=3[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)=[N:10][CH2:11][C:5]2=[N:4][N:3]=1.[OH:22][CH2:23][CH2:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[OH:22][CH2:23][CH2:24][N:25]1[CH2:30][CH2:29][N:28]([C:2]2[N:6]3[C:7]4[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=4[C:9]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=4)=[N:10][CH2:11][C:5]3=[N:4][N:3]=2)[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 21492763HCID 21492763, compound

Product 1

HCID 21492827HCID 21492827, compound

Procedure

In the manner given in Example 1, 1-bromo-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated with excess 1-(β-hydroxyethyl)piperazine to give 1-[4-(β-hydroxyethyl)piperazino]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-a3fd9e218aa842bfbef8073efa8ca1f9
Source dataset
uspto-grants-1976_12
Patent number
US03996230

Reaction notes

Loading…