1-(2-Hydroxyethyl)piperazine → HCID 21492824, compound

HRID 1973141Notes

Reaction equation

HRID 1973141 reaction equation
Br[C:2]1[N:6]2[C:7]3[CH:22]=[CH:21][C:20]([Br:23])=[CH:19][C:8]=3[C:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=3)=[N:10][CH:11]([CH3:12])[C:5]2=[N:4][N:3]=1.[OH:24][CH2:25][CH2:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[Br:23][C:20]1[CH:21]=[CH:22][C:7]2[N:6]3[C:2]([N:30]4[CH2:31][CH2:32][N:27]([CH2:26][CH2:25][OH:24])[CH2:28][CH2:29]4)=[N:3][N:4]=[C:5]3[CH:11]([CH3:12])[N:10]=[C:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=3)[C:8]=2[CH:19]=1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 21492820HCID 21492820, compound

Product 1

HCID 21492824HCID 21492824, compound

Procedure

In the manner given in Example 1, 1,8-dibromo-4-methyl-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated with excess of 1-(β-hydroxyethyl)piperazine to give 8-bromo-4-methyl-1-[4-(β-hydroxyethyl)piperazino]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-40b916b51146427e997ff6ab64364140
Source dataset
uspto-grants-1976_12
Patent number
US03996230

Reaction notes

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