HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 3-Ethynyl-1-iodooct-1-en-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 1-Iodo-1-octen-3-ol | HCID 53420223 | — |
| Reactant | HCID 178418486 | HCID 178418486 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Ethynyl-1-iodooct-1-en-3-ol | HCID 54114526 | — |
Reaction Steps
As shown in FIG. 1, 1-iodo-1-octen-3-ol (II) is treated with an ethynyl Grignard reagent, conveniently ethynyl magnesium bromide, in a suitable Grignard solvent of the ether type, conveniently tetrahydrofuran, at reduced temperature, conveniently 0° C., while stirring for a short time, conveniently 1 hour, to give dl-3-ethynyl-1-iodo-1-octen-3-ol (III).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03996255 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-450e3978e8754ef78389b80243971944 |
| Source note | uspto-grants-1976_12 |