反应详情

A solution of 8.8 g. of 7-(5-oxo-1-cyclopentenyl)-cis-5-heptenoic acid, methyl ester and 6.6 g. of tris-(triphenylphosphine) rhodium (I) chloride in 800 ml. of 1:1 benzene-ethanol is hydrogenated at 25° and atmospheric pressure until 1 equivalent of hydrogen was absorbed. The solvents are evaporated and the resulting residue dissolved in 1:1 ethyl acetate-hexane and flushed through a silica column. The crude product is then rechromatographed on silica with 15% ethyl acetate in hexane to obtain 7.2 g. of the title product as an oil.

1. customis hydrogenated at 25°
2. customThe solvents are evaporated
3. dissolutionthe resulting residue dissolved in 1:1 ethyl acetate-hexane
4. customflushed through a silica column
5. customThe crude product is then rechromatographed on silica with 15% ethyl acetate in hexane
6. customto obtain 7.2 g