HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfur → 4-(Methylsulfanyl)-2-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfur | HCID 5362487 | — |
| Reactant | HCID 22768209 | HCID 22768209 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(Methylsulfanyl)-2-(trifluoromethyl)aniline | HCID 13070055 | — |
Reaction Steps
2-Nitro-5-methylthiobenzotrifluoride (190 g, 0.85 mole) in ethanol (1 l.) is reduced over Raney nickel at about 45 psi of hydrogen gas. After hydrogen uptake is complete the catalyst is deactivated with elemental sulfur, the mixture is filtered, and the filtrate evaporated under reduced pressure to afford the desired product as an oil. IR 2.9 μ (strong NH band).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03996277 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-fa15c1c88f54447a99996e4dc0495744 |
| Source note | uspto-grants-1976_12 |