Chloroacetyl chloride → HCID 21493342, compound

Participants

Reaction Steps

A solution of 2-chloro-3-amino-6-ethoxypyridine (17 grams) in ether (200 ml), and triethylamine (10 grams) are placed in a glass reaction flask equipped with stirrer, thermometer and addition funnel. The mixture is cooled to about 0° to 10° C and a solution of chloroacetyl chloride (11.3 grams) in ether (40 ml) is slowly added thereto over a period of about 30 minutes resulting in the formation of a precipitate. The precipitate is recovered by filtration and is washed first with aqueous sodium bicarbonate and then with water. The washed product is then dried to yield the desired product N-(2-chloro-6-ethoxy-3-pyridyl)-α-chloroacetamide.

Provenance & Evidence