Isopropylamine → HCID 21493395, compound

HRID 1973238Notes

Reaction equation

HRID 1973238 reaction equation
[CH:1]([NH:4][C:5]1[N:13]=[CH:12][N:11]=[C:10]2[C:6]=1[N:7]=[CH:8][N:9]2[CH2:14][CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][N:20]([C:23]2[CH:28]=[CH:27][C:26](F)=[CH:25][CH:24]=2)[CH2:19][CH2:18]1)([CH3:3])C.Cl[C:31]1N=CN=C2C=1N=CN2CCCN1CCN(C2C=CC(F)=CC=2)CC1.C(N)(C)C>>[CH2:1]([NH:4][C:5]1[N:13]=[CH:12][N:11]=[C:10]2[C:6]=1[N:7]=[CH:8][N:9]2[CH2:14][CH2:15][CH2:16][N:17]1[CH2:18][CH2:19][N:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:21][CH2:22]1)[CH2:3][CH3:31]

Participants

4

Reactant 3

HCID 6363IsopropylamineHCID 21493397HCID 21493397, compoundHCID 86734244HCID 86734244, compound

Product 1

HCID 21493395HCID 21493395, compoundYield 58%

Procedure

N6 -isopropyl-9-{3-[4-(4-fluorophenyl)-piperazino]-propyl}-adenine from 6-chloro-9-{3-[4-(4-fluorophenyl)-piperazino]-propyl}-purine and isopropylamine; yield 58% of theory; m.p. of the dihydrochloride 232°-233° C after recrystallization from methanol.

Workup

  1. customm.p. of the dihydrochloride 232°-233° C after recrystallization from methanol

Sources & evidence

ORD record
ord-a873fd0c2e764db1b78bfffb9859a042
Source dataset
uspto-grants-1976_12
Patent number
US03996361

Reaction notes

Loading…