Methylhydrazine → HCID 178499537, compound

Participants

Reaction Steps

23 g of monomethylhydrazine were added to 87 g (0.5 mole) of acetonedicarboxylic acid dimethyl ester in 200 ml of methanol, during which the reaction temperature rose to 65° C. After completion of the addition, the mixture was stirred for a further 2 hours and 0.5 mole of sodium methylate in methanol was then added. The reaction was slightly exothermic. The reaction mixture was stirred for a further 2 hours and evaporated, and the residue was dissolved in water. After acidification with glacial acetic acid, the precipitate was filtered off, dried and recrystallized from an ethyl acetate/acetonitrile mixture. 30 g (35% of theory) of 1-methyl-3-methoxycarbonylmethyl-5-hydroxypyrazole of melting point 148° C were obtained. ##SPC7##

Provenance & Evidence