HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzhydryl chloride → 1-(p-Chlorophenyl-phenylmethyl)-3-methyl-3-(3,4-dimethoxybenzyl)-piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzhydryl chloride | HCID 241584 | — |
| Reactant | HCID 20363969 | HCID 20363969 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 1-(p-Chlorophenyl-phenylmethyl)-3-methyl-3-(3,4-dimethoxybenzyl)-piperazine | HCID 21428573 | 80% |
Reaction Steps
If 3-methyl-3-(3,4-dimethoxybenzyl)-piperazine is reacted with p-chlorophenyl-phenylmethyl chloride in methyl ethyl ketone according to Example 2, 1-(p-chlorophenyl-phenylmethyl)-3-methyl-3-(3,4-dimethoxybenzyl)-piperazine is obtained in 80 percent yield after a twelve-hour reaction period. The hydrochloride has a melting point of 235° - 237° C. (isopropanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03996360 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-135fec41412a45d68875686baf13d7cf |
| Source note | uspto-grants-1976_12 |