HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazepam → Methyl 5-chloro-3-phenyl-2H-isoindole-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazepam | HCID 3016 | — |
| Reactant | Dimethyl Carbonate | HCID 12021 | — |
| Product | Methyl 5-chloro-3-phenyl-2H-isoindole-1-carboxylate | HCID 53969048 | — |
Reaction Steps
The starting material can be prepared from 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one and dimethylcarbonate in a manner analogous to that described in Example 1. After recrystallization from acetone, there is obtained 5-chloro-3-phenylisoindole-1-carboxylic acid methyl ester; melting point 208°-210° C. (decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03996374 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-c114acc9d62b4995b63d17d4f47df13f |
| Source note | uspto-grants-1976_12 |