Diethyl Ether → HCID 178470183, compound

HRID 1973339Notes

Reaction equation

HRID 1973339 reaction equation
[ClH:1].C(S[C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[NH:11])C1C=CC=CC=1.[NH2:18][CH:19]([C:25]#[N:26])[C:20]([O:22][CH2:23][CH3:24])=[O:21].C(OCC)C>C(Cl)(Cl)Cl>[ClH:1].[NH2:26][C:25]1[NH:11][C:10]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[N:18][C:19]=1[C:20]([O:22][CH2:23][CH3:24])=[O:21]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 288716Ethyl 2-amino-2-cyanoacetateHCID 21491190Benzyl benzenecarboximidothioate--hydrogen chloride (1/1)

Product 1

HCID 178470183HCID 178470183, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Phenylformimino benzyl thioether hydrochloride (28.5gm) was refluxed in chloroform (200 ml) with ethyl aminocyanoacetate (17.0gm) for 1 hour. On standing for 8 hours the addition of dry diethyl ether (250 ml) caused the precipitation of the 5-amino-4-carbethoxy-2-phenylimidazole hydrochloride (24.5gm) m.p. 228° C after recrystallisation from ethanol.

Workup

  1. customthe precipitation of the 5-amino-4-carbethoxy-2-phenylimidazole hydrochloride (24.5gm) m.p. 228° C
  2. customafter recrystallisation from ethanol

Sources & evidence

ORD record
ord-863fab730cb44556a1679fb31514b0a7
Source dataset
uspto-grants-1976_12
Patent number
US03997518

Reaction notes

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