3-Chloroquinoxaline-2-carboxylic acid → HCID 178522730, compound

Participants

Reaction Steps

3-Chloro-2-quinoxalinecarboxylic acid (1.5 g) and N,N'-carbonyldiimidazole (1.2 g) in tetrahydrofuran (50 ml) were heated under reflux for 15 minutes. 5-Amino-1H-tetrazole (0.7 g) in dimethylformamide (5 ml) was added and the solution heated under reflux for 1 hour. The solvent was distilled off and the residue was triturated with dilute hydrochloric acid (25 ml., 2N). The solid was collected and crystallised from aqueous dimethylformamide. It had m.p. 257°-260° (d) (38%).

Provenance & Evidence