HCID 131710569, compound → HCID 178422308, compound

Participants

Reaction Steps

4-(3-Dimethylaminopropyl)-3,4-dihydro-6,7-dimethyl-3-oxo-2-quinoxalinecarboxylic acid, hydrochloride (Example 18b) (0.26 g) and N,N'-carbonyldiimidazole (0.14 g) in dimethylformamide (5 ml) were heated at 100° for 5.5 hours. 5-Amino-1H-tetrazole (0.78 g) was added and heating at 100° was continued for 1 hour. The solid was collected and dissolved in hot aqueous dimethylaminoethanol (8 ml) (5%) and the solution was acidified with 2N hydrochloric acid. The solid that crystallised as the solution cooled was collected and dried. It had m.p. 280°-283° (d) (14%).

Provenance & Evidence