Boron tribromide → 56911-04-7

HRID 1973396Notes

Reaction equation

HRID 1973396 reaction equation
C[O:2][C:3]1[C:8]2=[CH:9][S:10][N:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1.B(Br)(Br)Br>C(Cl)Cl>[OH:2][C:3]1[C:8]2=[CH:9][S:10][N:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 122558002,1-Benzisothiazole, 4-methoxy-

Product 1

HCID 13579433756911-04-7

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 6.3 g. 4-methoxy-2,1-benzisothiazole, 28.5 g. boron tribromide, and 180 ml. methylene chloride was heated at reflux temperature 17 hours to give 5.1 g. 4-hydroxy-2,1-benzisothiazole as a yellow solid, mp. 184.5°-186.5° after recrystallization from benzene. This structure was confirmed by nmr.

Workup

  1. additionA mixture of 6.3 g
  2. temperatureat reflux temperature 17 hours
  3. customto give 5.1 g
  4. custom4-hydroxy-2,1-benzisothiazole as a yellow solid, mp. 184.5°-186.5° after recrystallization from benzene

Sources & evidence

ORD record
ord-aab8b1d7d455445fbbef07ee26460dc7
Source dataset
uspto-grants-1976_12
Patent number
US03997548

Reaction notes

Loading…