HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2,1-Benzothiazol-7-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 7-Methoxy-2,1-benzisothiazole | HCID 12255802 | — |
| Reactant | HCID 21491447 | HCID 21491447 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,1-Benzothiazol-7-ol | HCID 21491443 | — |
Reaction Steps
7-Methoxy-2,1-benzisothiazole was dissolved in ether and converted to the hydrochloride using dry hydrogen chloride gas. The 7-methoxy-2,1-benzisothiazole hydrochloride (6.0 g.) was refluxed 22 hours in a solution of 16 g. boron tribromide and 160 ml. methylene chloride to give 3.78 g. pure, yellow, crystalline 7-hydroxy-2,1-benzisothiazole, mp. 99°-100.5° after recrystallization from hexane. This structure was confirmed by nmr.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03997548 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-29bb1d2c20524980ad92a437f64b1594 |
| Source note | uspto-grants-1976_12 |