HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl 5H-Cyclopenta[b]pyridine-6,6(7H)-dicarboxylate | HCID 21260369 | — |
| Product | 6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid hydrochloride | HCID 68562899 | — |
Reaction Steps
5,7-Dihydro-[1]pyrindine-6,6-dicarboxylic acid diethyl ester (0.953 g, 3.62 mmol) is taken into concentrated hydrochloric acid, heated to reflux for 4 hours and evaporated to afford 6,7-dihydro-5H-[1]pyrindine-6-carboxylic acid hydrochloride. δc (DMSO-d6) 33.9 (t), 34.5 (t) 41.2 (d), 124.8 (d), 140.1 (d), 140.8 (d), 141.2 (s), 158.4 (s), 175.2 (s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745462B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-d044b15e3bc640e38db51ed53b337563 |
| Source note | uspto-grants-2010_06 |