HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl (ethoxymethylene)malonate → 1,3-Diethyl 2-[[[5-chloro-3-(methoxycarbonyl)-2-thienyl]amino]methylene]propanedioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | Methyl 2-amino-5-chlorothiophene-3-carboxylate | HCID 13217726 | — |
| Product | 1,3-Diethyl 2-[[[5-chloro-3-(methoxycarbonyl)-2-thienyl]amino]methylene]propanedioate | HCID 13217728 | — |
Reaction Steps
Reaction of methyl 2-amino-5-chlorothiophene-3-carboxylate with diethyl ethoxymethylenemalonate in a similar manner to that used in Reference Example 10 yields diethyl (5-chloro-3-methoxycarbonylthienyl)aminomethylenemalonate as crystals melting at 89.5°-90.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03997545 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-2013d5ea71ed47ed8e6cb23b16494e9b |
| Source note | uspto-grants-1976_12 |