反应详情

A mixture of 10 g. of 2-(m-trifluoromethylphenyl)-3-dimethylaminoacrolein, 5 g. of 2-hydroxybutylhydrazine and 100 ml. of benzene is refluxed for 2.5 hours. The benzene is evaporated off, ether added, and the reaction mixture cooled to obtain a precipitate which is recovered by filtering, washed with pentane, dissolved in methylene chloride, dried, treated with charcoal and filtered. The resulting solution is treated by addition of pentane and the resulting precipitate recovered by filtering, washed with pentane and dried under reduced pressure to obtain 1-(2-hydroxybutyl)-4-(m-trifluoromethylphenyl)-pyrazole, m.p. 77°-79°C.

1. additionA mixture of 10 g
2. customThe benzene is evaporated off
3. additionether added
4. temperaturethe reaction mixture cooled
5. customto obtain a precipitate which
6. customis recovered
7. filtrationby filtering
8. washwashed with pentane
9. dissolutiondissolved in methylene chloride
10. customdried
11. additiontreated with charcoal
12. filtrationfiltered
13. additionThe resulting solution is treated by addition of pentane
14. customthe resulting precipitate recovered
15. filtrationby filtering
16. washwashed with pentane
17. customdried under reduced pressure