HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → 1-isopropyl-4-phenyl-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinthione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | N-isopropyl-N-(3,4-methylenedioxyphenyl)thiourea | HCID 12789468 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-isopropyl-4-phenyl-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinthione | HCID 12789481 | — |
Reaction Steps
A solution of 30 grams of N-isopropyl-N-(3,4-methylenedioxyphenyl)thiourea, 27.6 mls. of benzaldehyde, and 2 mls. of methanesulphonic acid in 500 ml. of toluene is refluxed under a Dean Stark water separator for 4 hours, during which 2 ml. water is collected. The filtered solution is then evaporated to yield a powder. This product is recrystallized from dioxane and water to obtain 1-isopropyl-4-phenyl-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinthione, m.p. 215°-218°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03997564 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-e010a382348e47a89fb7dc843686dc22 |
| Source note | uspto-grants-1976_12 |