反应详情

A mixture of 2 grams of 1-isopropyl-4-phenyl-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinthione, 100 ml. of methylene chloride and 4 grams of manganese dioxide is stirred for 48 hours at room temperature. Precipitated solids are removed by filtration and the filtrate evaporated to dryness. The residue is recrystallized from ethyl acetate and then methanol and then eluted with benzene in a silica gel column to give 1-isopropyl-4-phenyl-6,7-methylenedioxy-2(1H)-quinazolinthione, m.p. 202°-205°C.

1. customPrecipitated solids
2. customare removed by filtration
3. customthe filtrate evaporated to dryness
4. customThe residue is recrystallized from ethyl acetate
5. washmethanol and then eluted with benzene in a silica gel column