反应详情

3-Nitrophthalimide is converted to the potassium salt by the procedure described in Example 13 and then reacted with 1-(2-chloroethyl)-2-methyl-5-nitroimidazole according to the procedure described in Example 1. The crude reaction mixture is digested with toluene and then filtered to remove some insoluble material. Evaporation of the solvent leaves a syrup which is diluted with chloroform and then filtered to remove some insoluble material. The filtrate is further diluted with toluene and again filtered to remove some precipitate. The solvent is then evaporated from the filtrate and the resulting residue is recrystallized first from ethanol and then from acetone to give N-[2-(2-methyl-5-nitro-1-imidazolyl)ethyl]-3-nitrophthalimide melting at about 175°-176° C.

1. customThe crude reaction mixture
2. filtrationfiltered
3. customto remove some insoluble material
4. customEvaporation of the solvent
5. customleaves a syrup which
6. filtrationfiltered
7. customto remove some insoluble material
8. additionThe filtrate is further diluted with toluene
9. filtrationagain filtered
10. customto remove some precipitate
11. customThe solvent is then evaporated from the filtrate
12. customthe resulting residue is recrystallized first from ethanol