Water → Cyclohexanone, 2-[2-(4-bromophenyl)-2-oxoethyl]-

Participants

Reaction Steps

A suspension of 50 g (0.18 mole) of p-bromophenacyl bromide in 215 ml. of toluene is added in small portions to a stirred boiling solution of 27.2 g (0.18 mole) of 1-pyrrolidino-1-cyclohexene in 90 ml. of toluene. The mixture is heated under reflux for 2 hours, diluted with 90 ml. of water and refluxed for 3 hours. The layers are separated and the aqueous phase is extracted with ether. The organic solution is dried over sodium sulfate and concentrated to an oil which solidifies. The solid is recrystallized from a cyclohexane-ethanol mixture to give 2-(p-bromophenacyl)-cyclohexanone as colorless crystals, m.p. 78°-80° C.

Provenance & Evidence