反应详情

A stirred mixture of 15.9 g (0.11 mole) of 1-pyrrolidino-1-cyclohexene, 28.0 g (0.11 mole) of m-trifluoromethylphenacyl bromide, and 100 ml. of toluene is heated under reflux for 2 hours, diluted with water, and refluxed for 2 hours. The layers are separated, and the organic phase is dried and concentrated to a liquid. Distillation provides 2-(m-trifluoromethylphenacyl)cyclohexanone as a liquid, b.p. 137°-138° C. (0.075 mm).

1. temperatureunder reflux for 2 hours
2. temperaturerefluxed for 2 hours
3. customThe layers are separated
4. customthe organic phase is dried
5. concentrationconcentrated to a liquid
6. distillationDistillation