2-Bromo-1-(4-hydroxyphenyl)ethanone → Cyclohexanone, 2-[2-(4-hydroxyphenyl)-2-oxoethyl]-

Participants

Reaction Steps

43 g (0.2 mole) of (p-hydroxyphenacyl bromide) are added dropwise during 1/2 hour to a cooled (25° C) solution of 30 g (0.2 mole) of 1-pyrrolidino-1-cyclohexene in dimethylformamide. After 51/2 hours, the solution is diluted with water and extracted with chloroform. The chloroform solution is washed with water, dried over sodium sulfate and concentrated to an oil. Distillation gives a liquid which solidifies to give 2-(p-hydroxyphenacyl) cyclohexanone, m.p. 120°-125° C.

Provenance & Evidence